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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
We utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid of Neuro-COVID patients and discovered an expansion of dedifferentiated monocytes and exhausted CD4+ T cells.
Michael Heming
,
Xiaolin Li
,
Saskia Räuber
,
Anne K Mausberg
,
Anna-Lena Börsch
,
Maike Hartlehnert
,
Arpita Singhal
,
I-Na Lu
,
Michael Fleischer
,
Fabian Szepanowski
,
Oliver Witzke
,
Thorsten Brenner
,
Ulf Dittmer
,
Nir Yosef
,
Christroph Kleinschnitz
,
Heinz Wiendl
,
Mark Stettner
,
Gerd Meyer zu Hörste
Cite
Shiny app
Manuscript
Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis
Distinguishing neurosarcoidosis (NS) from multiple sclerosis (MS) remains challenging and available parameters lack discriminatory …
Michael Heming
,
Lisa Lohmann
,
Andreas Schulte-Mecklenbeck
,
Tobias Brix
,
Catharina C Gross
,
Heinz Wiendl
,
Luisa Klotz
,
Gerd Meyer zu Hörste
Cite
Shiny app
Manuscript
Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity.
Peripheral nerves contain axons and their enwrapping glia cells named Schwann cells (SCs) that are either myelinating (mySCs) or …
Jolien Wolbert
,
Xiaolin Li
,
Michael Heming
,
Anne K Mausberg
,
Dagmar Akkermann
,
Clara Frydrychowicz
,
Robert Fledrich
,
Linda Groeneweg
,
Christian Schulz
,
Mark Stettner
,
Noelia Alonso Gonzalez
,
Heinz Wiendl
,
Ruth Stassart
,
Gerd Meyer zu Hörste
Cite
Shiny app naive mouse
Shiny app mouse
Manuscript
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our …
David Schafflick
,
Chenling A Xu
,
Maike Hartlehnert
,
Michael Cole
,
Andreas Schulte-Mecklenbeck
,
Tobias Lautwein
,
Jolien Wolbert
,
Michael Heming
,
Sven G Meuth
,
Tanja Kuhlmann
,
Catharina C Gross
,
Heinz Wiendl
,
Nir Yosef
,
Gerd Meyer zu Hörste
Cite
DOI
Pretreatment anti-thyroid autoantibodies indicate increased risk for thyroid autoimmunity secondary to alemtuzumab: A prospective cohort study
BACKGROUND: Alemtuzumab is approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). Alemtuzumab-related …
Tobias Ruck
,
Andreas Schulte-Mecklenbeck
,
Steffen Pfeuffer
,
Michael Heming
,
Luisa Klotz
,
Susanne Windhagen
,
Christoph Kleinschnitz
,
Catharina C Gross
,
Heinz Wiendl
,
Sven G Meuth
Cite
DOI
Immune cell profiling of the cerebrospinal fluid provides pathogenetic insights into inflammatory neuropathies
Objective: Utilize immune cell profiles in the cerebrospinal fluid (CSF) to advance the understanding and potentially support the …
Michael Heming
,
Andreas Schulte-Mecklenbeck
,
Tobias Brix
,
Jolien Wolbert
,
Tillmann Ruland
,
Luisa Klotz
,
Sven G Meuth
,
Catharina C Gross
,
Heinz Wiendl
,
Gerd Meyer zu Hörste
Cite
DOI
Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids
Although glucocorticoids (GC) represent the most frequently used immunosuppressive drugs, their effects are still not well understood. …
Michael Heming
,
Sandra Gran
,
Saskia-L Jauch
,
Lena Fischer-Riepe
,
Antonella Russo
,
Luisa Klotz
,
Sven Hermann
,
Michael Schäfers
,
Johannes Roth
,
Katarzyna Barczyk-Kahlert
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DOI
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